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Title   간경변이 동반된 간세포암에서 근치적 절제후 절제연이 재발양상에 미치는 영향 ( Effect of Surgical Margin on the Recurrence after Curative Resection for Hepatocellular Carcinoma associated with Cirrhosis )
Publicationinfo   1993 Jan; 025(04): 488-494.
Key_word   Hepatocellular carcinoma, Cirrhosis, Resection margin
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Abstract   We studied to elucidate whether surgical margin is related to recurrence after curative resection of hepatocellular carcinoma in patient with cirrhosis. Forty patients who underwent curative hepatic resection for hepatocellular carcinoma with cirrhosis between Jan 1988 and Dec l989 and met the following criteria(histologically preven cirrhosis, solitary nodule less than 10 cm, resection less than formal segmentectomy, no evidence of direct invasion or metastasis) were included in this study. Resection margin was expressed as RMO and RM1 when resection margin is less than 1 cm and equai to or greater than 1cm, respectively. There was no statistical difference in the recurrence free rate curve between RMO(n =25) and RM1(n= 15). In patients with tumor size equal to or greater than 4 cm, there was no statistical difference in the recurrence free rate curve between RMO(n= 12) and RMl(n=5). But in patients with tumor size less than 4 cm, there was significant difference between RMO(n=13) and RM1(n=10). In conclusion, in case of small hepatocellular carcinoma, we can reduce the intraheptic re- currence rate with larger resection margin as long as liver reserve function is permitted. But in large hepatocellular carcinoma, recurrence cannot be reduced with large resection margin, so another therapeutic modality may be necessary.
저 자   서경석(Kyung Suk Suh),이건욱(Kuhn Uk Lee),김수태(Soo Tae Kim)